These drugs — including Prozac, Paxil, Zoloft, Celexa, and Lexapro — alter the way the body handles the “feel-good” brain chemical serotonin — a hormone responsible for regulating mood and happiness. As a result, things that once provoked strong reactions may now leave the same individual unaffected or even apathetic.
An unwanted side effect of SSRIs, especially — though not only — in people taking them for a long time, is a diminished emotional response to both unpleasant and pleasurable events, referred to as “ emotional blunting .”
About half of users who take selective serotonin reuptake inhibitors (SSRIs) report a sense of emotional blunting, a psychic flatness that limits their emotional range, particularly their ability to experience positive feelings like pleasure and joy.
Escitalopram may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
4 According to the research, the antidepressants most commonly associated with emotional blunting are: Selective norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine), Pristiq (desvenlafaxine), and Effexor XR (venlafaxine)
Patients on SSRI antidepressants feel numb because the drug reduces reinforcement sensitivity, that is, our sensitivity to positive feedback, which you can also call rewards or pleasure.
A common side-effect among anti-depressants users is feeling emotionally numb or experiencing emotional blunting. Their hobbies are no longer fun. And their sex life is not as pleasurable as it used to. Researchers estimate that between 40% to 60% of people who take antidepressants experience this side effect.
In post-hoc analyses, escitalopram seemed to have an effect on agreeableness. Further, a trend was found for increased conscientiousness. Thus it is possible that SSRIs may have an effect on aspects of personality such as agreeableness and conscientiousness independent of the treatment effect on depression.
“If your depression symptoms get worse as soon as you start taking an antidepressant, or they get better and then very suddenly get worse, it's a sign that the depression medication isn't working properly, and you should see your healthcare professional right away,” Hullett says.
Common side effects of Lexapro include nausea, sexual side effects, and insomnia. For some people, these go away as your body gets used to the medication. More serious side effects of Lexapro are rare. These include suicidal thoughts or behaviors, abnormal bleeding, and serotonin syndrome.
Emotional blunting can be temporary, lasting from a few minutes to a few hours at a time. It can also occur over the long term, from months to years. It all depends on the underlying cause. Experiencing emotional blunting may affect your relationships and how you feel about yourself and the world.
Antidepressants like escitalopram help to improve or lift your mood so you feel better. You may notice that you sleep better and get on with people more easily because you're less anxious. You will hopefully be more relaxed about things that used to worry you. Escitalopram will not change your personality.
It's common for some symptoms — like improved energy, sleep, and appetite — to improve within a week or two. However, other symptoms — like being uninterested in activities and having depressive feelings — might take up to 6 – 8 weeks before seeing improvement.
One of the widely-reported side effects of SSRIs is 'blunting', where patients report feeling emotionally dull and no longer finding things as pleasurable as they used to.
In the case of SSRIs, SNRIs, and related medications, the effects of taking antidepressants when not depressed can include developing a condition known as serotonin syndrome. Symptoms of this condition include the following: Confusion. Agitation.
(If a person who isn't depressed takes antidepressants, they do not improve that person's mood or functioning - it's not a "happy pill.") Rarely, people experience apathy or loss of emotions while on certain antidepressants. When this happens, lowering the dose or switching to a different antidepressant may help.
The drugs and supplements that could potentially cause serotonin syndrome include: Selective serotonin reuptake inhibitors (SSRIs), antidepressants such as citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle) and sertraline (Zoloft)
In addition to reducing interest in sex, SSRI medications can make it difficult to become aroused, sustain arousal, and reach orgasm. Some people taking SSRIs aren't able to have an orgasm at all. These symptoms tend to become more common with age.
Lexapro (escitalopram) is a depression medication that may cause sexual side effects for some, such as low sex drive in both men and women, difficulty reaching orgasm in women, and delayed ejaculation in men. A medical provider may advise either a change in dosage or a different medication to avoid these effects.
Lexapro is usually taken for a period of many years, either until a person feels that they don't need it anymore or until they begin experiencing negative side effects and decide to switch medications. However, ceasing to take Lexapro should not be undertaken lightly—or without clinical oversight.
Selective serotonin reuptake inhibitors (SSRIs)
SSRIs are the antidepressant class most linked to emotional blunting. SSRIs include: Escitalopram (Lexapro) Fluoxetine (Prozac)
After three months of antidepressant treatment, the research revealed relevant differences: patients reported their level of empathy to be lower, and brain activation was reduced in areas previously associated with empathy.
Derealisation refers to a similar set of feelings and perceptions, but in this case it is the world itself that seems strange or unreal; everything may seem far away or staged in some way – as though life is being watched rather than lived. Depersonalisation and derealisation are relatively common on antidepressants.