While it is true that almost all people with MS will have evidence of brain lesions on MRI, not all people with brain lesions have MS.
MS activity appears on an MRI scan as either bright or dark spots. Typical MS lesions tend to be oval or frame shaped. MS lesions can appear in both the brain's white and gray matter. Healthcare professionals may use a chemical contrast dye called gadolinium to improve the brightness of MRI scan images.
MRI has greater than 90% sensitivity in the diagnosis of MS; however, other white matter diseases can sometimes have a similar appearance on medical imaging.
It's most commonly diagnosed in people in their 20s, 30s and 40s although it can develop at any age. It's about 2 to 3 times more common in women than men. MS is one of the most common causes of disability in younger adults.
Blood Tests: Currently, there are no definitive blood tests for diagnosing MS, but they can be used to rule out other conditions that may mimic MS symptoms, including Lyme disease, collagen-vascular diseases, rare hereditary disorders and acquired immune deficiency syndrome (AIDS).
MRI is particularly useful in detecting central nervous system demyelination — that is, damage of the myelin sheath in the nervous system. This makes it a powerful tool in establishing the diagnosis of MS.
Although MRI is a very useful diagnostic tool, a normal MRI of the brain does not rule out the possibility of MS. About 5 percent of people who are confirmed to have MS do not initially have brain lesions evidenced by MRI.
Some of the most common mimics include migraine and chronic cerebrovascular disease, according to Dr Schiess. Vasculitic autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome can also result in white matter abnormalities on MRI.
Diagnosing MS
More than 90% of people with MS have scar tissue that shows up on an MRI scan. A spinal tap can check for abnormalities in the fluid that bathes the brain and spinal cord. Tests to look at electrical activity of nerves can also help with diagnosis.
MRI is considered the best test to help diagnose MS. However, 5% of people with MS do not have abnormalities detected on MRI; thus, a "negative" scan does not completely rule out MS. In addition, some common changes of aging may look like MS on a MRI. To track the progress of disease.
Sjogren's syndrome is an autoimmune disease that can mimic some of the symptoms of MS such as fatigue and joint pain.
Fatigue in MS is not just an ordinary tiredness, like you might get at the end of a hard day's work. People describe it as an overwhelming sense of tiredness with no obvious cause. You may wake up feeling as tired as you did when you went to sleep.
Magnetic resonance imaging (MRI)
It's very accurate and can pinpoint the exact location and size of any inflammation, damage or scarring (lesions). MRI scans confirm a diagnosis in over 90 per cent of people with MS.
Your doctor will refer you to a neurologist. They will examine you to check how different parts of your nervous system are working. A combination of tests is used to diagnose MS. The best test is an MRI of your brain and spinal cord to detect areas of damage.
Can I have multiple sclerosis for years and not know it? Yes. MS can go undetected for years. Research has suggested that many patients experience MS-related symptoms and signs several years before receiving a definite diagnosis of the disease.
How to self-assess multiple sclerosis symptoms. A multiple sclerosis (MS) self-assessment cannot diagnose MS, but it may help a person understand their symptoms and know when to contact a doctor. An MS self-assessment may focus on energy levels, physical sensations, vision problems, and more.
There are no specific tests for MS . Instead, a diagnosis of multiple sclerosis often relies on ruling out other conditions that might produce similar signs and symptoms, known as a differential diagnosis. Your doctor is likely to start with a thorough medical history and examination.
Contents. You may have to adapt your daily life if you're diagnosed with multiple sclerosis (MS), but with the right care and support many people can lead long, active and healthy lives.
Multiple sclerosis itself is not usually lethal, but it can increase the risk of long-term complications, such as infections or trouble swallowing, that can potentially shorten survival. On average, longevity is about five to 10 years shorter in people with MS.
Multiple sclerosis is caused by your immune system mistakenly attacking the brain and nerves. It's not clear why this happens but it may be a combination of genetic and environmental factors.
A person with benign MS will have few symptoms or loss of ability after having MS for about 15 years, while most people with MS would be expected to have some degree of disability after that amount of time, particularly if their MS went untreated.
Neurological examination
Your neurologist will look for abnormalities, changes or weakness in your vision, eye movements, hand or leg strength, balance and co-ordination, speech and reflexes. These may show whether your nerves are damaged in a way that might suggest MS.