Many people who take statins have reported changes in their memory or feeling like they have a foggy head. These are examples of cognitive side effects, meaning they affect how someone thinks.
All of these issues started shortly (typically within days to weeks) after these individuals started taking statins. The good news for anyone who experiences cognitive decline related to starting statins? The brain fog goes away when you stop taking the drugs.
Neurological side effects
The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins. These side effects reverse once you stop taking the medication.
Statins have been linked to short-term reversible cognitive impairment since early safety and tolerability testing [13]. During a phase I clinical trial of atorvastatin, escalating doses showed a dose-dependent adverse reaction of mild, transient, restlessness, euphoria, and mental confusion [13].
Results: Of the 60 patients identified who had memory loss associated with statins, 36 received simvastatin, 23 atorvastatin, and 1 pravastatin. About 50% of the patients noted cognitive adverse effects within 2 months of therapy. Fourteen (56%) of 25 patients noted improvement when the statin was discontinued.
Remember that even if evidence shows that statins cause memory problems, it may not be a common problem—and it may even be reversible. If a person stopped taking the medication, the effect would likely improve. If you have been prescribed a statin, never stop taking it without talking to your healthcare provider.
Psychiatric adverse effects, altering mood, personality, and behavior, sometimes arise in patients receiving statins. Statin psychiatric effects can include irritability/aggression, anxiety or depressed mood, violent ideation, sleep problems including nightmares, and possibly suicide attempt and completion.
In total, a pooled analysis of 36 studies found that statins were associated with a decreased risk of dementia (OR 0.80 (CI 0.75-0.86).
Fear of side effects and perceived side effects are the most common reasons for declining or discontinuing statin therapy. Willingness to take a statin is high, among both patients who have declined statin therapy and those who have never been offered one.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so. To understand more about your heart health, take a health risk assessment at Baptist Health.
An alternative medication, bempedoic acid, significantly lowers cholesterol and the risk of heart attacks, as well as reducing the need for a procedure that unblocks clogged arteries, according to a large clinical trial presented Saturday at the annual meeting of the American College of Cardiology.
Statin therapy may be associated with a variety of musculoskeletal disorders, including myopathy, myalgias, muscle weakness, back conditions, injuries, and arthropathies. These disorders may be particularly problematic in older people and may contribute to physical deconditioning and frailty.
Anyone who wants to stop taking a statin should talk to a doctor. In some cases, coming off these drugs can be dangerous. The doctor may suggest reducing the dosage, combining the statin with another cholesterol lowering drug, or switching to another drug entirely.
Rhabdomyolysis is the most serious adverse effect from statin use, though it occurs quite rarely (less than 0.1%). The most common risk factors for statin-related myopathy include hypothyroidism, polypharmacy and alcohol abuse.
If your risk is very low, you probably won't need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L). If your risk is very high — for example, you've had a heart attack in the past — a statin may be helpful even if you don't have high cholesterol.
Joseph A. Hill, M.D., Ph. D. The controversy in the United Kingdom started in 2013 when the British Medical Journal (BMJ) claimed statins were being overprescribed to people with low risk of heart disease, and that the drugs' side effects were worse than previously thought.
Official answer. It takes about 77 hours (3 days) for atorvastatin to be out of your system.
Brain fog is characterized by confusion, forgetfulness, and a lack of focus and mental clarity. This can be caused by overworking, lack of sleep, stress, and spending too much time on the computer.
Serious side effects
you get unexplained muscle pain, tenderness, weakness or cramps – these can be signs of muscle breakdown and kidney damage.