Zinc is released from cells called platelets that control blood clotting, and scientists have found unwanted blood clots can form when zinc levels in the blood are faulty.
Therefore, zinc accelerates clotting and reduces fibrin clot stiffness in a FXIII-independent manner, suggesting that zinc may work in concert with FXIII to modulate clot strength and stability. Keywords: FXIII; Zinc; clot structure; fibrin; fibrinogen.
According to MayoClinic.com, zinc may increase bleeding risk; hence, people suffering from bleeding disorders or taking medications that may increase bleeding risk should be wary of using zinc supplements and consult their health care providers regarding adjusted dosing.
Zinc serves for thrombus prevention as a ubiquitous modulator of haemostasis and thrombosis, aggregation, anti-coagulation and fibrinolysis that zinc controls blood clot formation on fibrin(ogen) expression and function, in which demonstrate its central role in clot formation during hemostasis and thrombosis [15].
Adverse effects of high zinc intake include nausea, vomiting, loss of appetite, abdominal cramps, diarrhea, and headaches. Intakes of 150–450 mg of zinc per day have been associated with such chronic effects as low copper status, altered iron function and reduced immune function.
Immunosuppressant medications -- Since zinc may make the immune system stronger, it should not be taken with corticosteroids (such a prednisone), cyclosporine, or other medications intended to suppress the immune system.
Vitamin K helps to make various proteins that are needed for blood clotting and the building of bones. Prothrombin is a vitamin K-dependent protein directly involved with blood clotting.
Vitamin K is a group of vitamins that the body needs for blood clotting, helping wounds to heal.
The researchers found that zinc affects the muscles, endothelial cells, and sensory nerves together, reducing the amount of calcium in the muscles and causing them to relax. This, in turn, results in increased blood flow and lower blood pressure.
Higher doses of zinc can lead to vomiting, headaches, diarrhea and exhaustion. Zinc may also interfere with many common prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs and immunosuppressant drugs.
What is zinc? Zinc is a mineral that is essential for many of the body's normal functions and systems, including the immune system, wound healing, blood clotting, thyroid function, and the senses of taste and smell. Zinc also supports normal growth and development during pregnancy, childhood and adolescence.
Warfarin (Coumadin®)
If you take warfarin, make sure that the amount of vitamin K you consume from food and supplements is about the same every day. A sudden change in the amount of vitamin K you get can cause dangerous bleeding (if you consume less) or blood clots (if you consume more).
Protein C deficiency is a disorder that increases the risk of developing abnormal blood clots; the condition can be mild or severe. Individuals with mild protein C deficiency are at risk of a type of blood clot known as a deep vein thrombosis (DVT).
We have found that magnesium increases the clotting time in plasma and in whole blood in a concentration-dependent fashion. Also, blood clotted in the presence of increased concentration of magnesium, has progressively shortened the lysis time of whole blood clots.
Calcium is a mineral which is important for clotting of blood. It also helps in building strong bones.
Vitamin B12 and Health
Vitamin B12 is involved in the breakdown of a protein called homocysteine. High homocysteine levels are associated with an increased risk of heart disease and stroke as it may promote the formation of blood clots and excess free radical cells, and may impair normal blood vessel function.
Foods rich in vitamin E, such as almonds, avocado, and spinach, can help dissolve blood clots. Vitamin E has anticoagulant properties and can help prevent blood clots from forming. It is recommended to consume foods rich in vitamin E regularly.
Vitamin K helps your blood to clot (thicken to stop bleeding). Warfarin works by making it harder for your body to use vitamin K to clot blood.
Vitamin D has been shown to have an anticoagulant effect.
Immunosuppressant medications -- Since zinc may make the immune system stronger, it should not be taken with corticosteroids (such as prednisone), cyclosporine, or other medications intended to suppress the immune system.
Together, zinc and vitamin D in adequate concentrations help maintain a healthy musculoskeletal system and beyond; however, deficiency in either of these nutrients can result in various disorders affecting almost all body systems.