Few studies had compared the effect of betahistine and metformin before. According to our study, although betahistine group failed to decrease the body weight significantly, it prevented further weight gain with a decreasing tendency.
In animal models (21, 22), parenteral betahistine reduced food intake. Barak et al (23) reported that betahistine, at doses ranging from 16 to 48 mg betahistine/d, did not have a significant effect on weight loss relative to a placebo over a 12-wk interval in 281 adults.
you get a skin rash that may include itchy, red, swollen, blistered or peeling skin. you're wheezing. you get tightness in the chest or throat. you have trouble breathing or talking.
Taking too much betahistine can make you feel sick or sleepy, or give you stomach ache.
The most commonly reported adverse events leading to drug discontinuation were tinnitus, vertigo, ear discomfort, and nervous system disorders, which were all more commonly reported with high dose betahistine than with low-dose betahistine treatment and placebo.
Your doctor may advise you to try betahistine for 6 to 12 months to see if it helps to reduce your symptoms. If it does, it can then be continued.
Do not stop taking this medicine suddenly, or change the dosage, without checking with your doctor. Do not use this medicine to treat any other complaints unless your doctor or pharmacist tells you to. Do not give this medicine to anyone else, even if they have the same condition as you.
Stop taking the medication and seek immediate medical attention if any of the following occur: signs of a serious allergic reaction (e.g., swelling of face or throat, hives, or difficulty breathing)
Some medicines and betahistine affect each other and can increase your chance of side effects. Tell your pharmacist or doctor if you're taking: medicines called MAO inhibitors, used to treat depression or Parkinson's disease. antihistamines for allergies such as hay fever.
Betahistine is unlikely to do you any harm, even if you take it for a long time. It's generally a very safe medicine.
It was taken off the market in the United States in 1970 because it was thought to be ineffective for vertigo, but is still used for this purpose in many other countries.
Keep taking your tablets until your doctor tells you to stop. Even when you start feeling better, your doctor may want you to carry on taking the tablets for some time to make sure that the medicine has worked completely.
This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol.
Anxiety symptoms
The repeated-measures ANOVA showed a significant effect of time (P<0.00001), indicating that both high-dose and low-dose betahistine could significantly reduce the HARS score.
Antihistamines, e.g. betahistine and cinnarizine. These are sedative, and patients should not operate machinery or drink alcohol.
Conclusion: Betahistine prevented PTZ-induced memory loss; an effect could be in part attributed to the enhanced cholinergic activity and GSK3-β inhibition.
Increases in vestibular blood flow and decreases in blood pressure were observed in response to betahistine infusions.
Vertigo has many different causes, and the treatments for it often do not work well. A previous Cochrane review found that betahistine reduced vertigo in people with one cause of vertigo (Meniere's disease).
Ginkgo biloba
It works by managing blood flow to the brain to relieve dizziness and balance issues. A study reported in the International Journal of Otolaryngology finds Ginkgo biloba is just as effective as the medication betahistine in managing vertigo.
The highest proportion of good or excellent clinical improvement scores were observed for nausea (89.9–90.2%), vomiting (82.4–82.7%) and faintness (87.9–88.2%) at end of treatment.
Betahistine is the analogue of histamine with weaker agonistic effect on histamine H1 receptors and stronger effect on histamine H3 receptors, while Cinnarizine has more effective effect on H1 receptors.
Medicinal Benefits
BETAHISTINE is indicated to treat symptoms such as ringing in your ears (tinnitus), dizziness, vertigo, loss of balance, and hearing loss associated with Meniere's disease. BETAHISTINE works by increasing the blood flow to your brain and by lowering the extra pressure build up in the inner ear.
feeling dizzy and a spinning sensation (vertigo) ringing in the ears (tinnitus) loss of hearing. feeling sick (nausea)