Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval. The manufacturers said the risk of side effects is rare, less than one in 10,000 doses sold.
Seizures in dogs are common, but it does appear that the risk increases when using Nexgard, Bravecto and Simparica.
Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.
This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Side Effects & Warnings
Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
The manufacturers says the risk of side effects is very rare, less than one in 10,000 doses sold. Seizures had been mentioned as a possible side effect of Simparica and the other three drugs, but only in very small print, sometimes on the back of the boxes and in the lengthy product inserts inside the boxes.
If your dog does have a history of seizures, it is advised to use different flea and tick medications than those mentioned above. Topical medications such as Advantage, Vectra, Revolution, or Frontline are good choices. Some dogs may have a localized reaction to topical medications.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
It starts working fast* and goes strong for 35 days. Simparica is FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
Sentinel is a heartworm, flea, and tick prevention medicine effective against intestinal worms. The chewable tablet is safe for puppies, pregnant dogs, and lactating dogs. It's also safe for dogs with epilepsy.
Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs).
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
Simparica is a chewable treatment for fleas, ticks and mites. You simply give one chew every 5 weeks to keep your dog protected.
Simparica is safe and effective in the treatment and prevention of flea infestations.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures.
Signal word Warning Hazard statement Very toxic to aquatic life with long lasting effects.
While most dogs and cats don't experience neurologic problems related to the treatments, seizures can occur in those even without a prior history. If your dog or cat experiences any health problems while using an isoxazoline treatment, talk to your veterinarian.
Oral Heartworm Medications
There are rarely side effects, if given at the proper dosage, but some dogs may experience vomiting, diarrhea, or incoordination. In the case of an allergic response to the heartworm medication, a dog may experience itching, hives, swelling of the face, or even seizures or shock.
Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 ...
The most common signs of toxicity from pyrethrum-based flea products are muscle tremors and excessive salivation. Common signs of toxicity from flea products containing organophosphates are diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling.