Bipolar disorder is frequently inherited, with genetic factors accounting for approximately 80% of the cause of the condition. Bipolar disorder is the most likely psychiatric disorder to be passed down from family. If one parent has bipolar disorder, there's a 10% chance that their child will develop the illness.
Defects in mitochondrial DNA sequences may contribute to a predisposition to such complex diseases as diabetes and bipolar disorder. Therefore, if all bipolar disorder patients have mitochondrial predisposition genes, then the transition of bipolar disorder from the mother's side would be higher.
Bipolar disorder may also be genetic or inherited. However, it will usually not be passed to children. About one in 10 children of a parent with bipolar disorder will develop the illness. Nine out of 10 will not.
Risk factors
Factors that may increase the risk of developing bipolar disorder or act as a trigger for the first episode include: Having a first-degree relative, such as a parent or sibling, with bipolar disorder. Periods of high stress, such as the death of a loved one or other traumatic event. Drug or alcohol abuse.
According to medical experts, bipolar disorder can also skip generations. Bipolar disorder is a complex condition, and scientists do not fully understand the role that genes play. A combination of many different genes likely increases a person's chance of developing this condition.
Genes. Bipolar disorder often runs in families, and research suggests this is mostly explained by heredity—people with certain genes are more likely to develop bipolar disorder than others. Many genes are involved, and no one gene can cause the disorder. But genes are not the only factor.
The Genomind Pharmacogenetic (PGx) test looks at 24 genes related to mental health treatment and can be used to help determine medication options to manage bipolar disorder.
Bipolar Triggers and Warning Signs
Bipolar disorder features extreme shifts in mood that are unpredictable and often disruptive to daily functioning. Changes in sleep patterns, eating habits, emotions, and behaviors accompany the mood swings.
Genetic factors and bipolar disorder
If one parent has bipolar disorder, there's a 10% chance that their child will develop the illness. If both parents have bipolar disorder, the likelihood of their child developing bipolar disorder rises to 40%.
The symptoms usually appear between the ages of 18 to 29 years, but they can occur at any age, including childhood and the teenage years. Bipolar disorder can be hard to diagnose, but there are signs or symptoms that you can look for.
They found that 12 risk genes for bipolar disorder were also linked to intelligence. In 75 % of these genes, bipolar disorder risk was associated with higher intelligence. In schizophrenia, there was also a genetic overlap with intelligence, but a higher proportion of the genes was associated with cognitive impairment.
Most studies, but not all, report an almost equal gender ratio in the prevalence of bipolar disorder but the majority of studies do report an increased risk in women of bipolar II/hypomania, rapid cycling and mixed episodes.
Drugs with a definite propensity to cause manic symptoms include levodopa, corticosteroids and anabolic-androgenic steroids. Antidepressants of the tricyclic and monoamine oxidase inhibitor classes can induce mania in patients with pre-existing bipolar affective disorder.
To diagnose bipolar disorder, a doctor performs a physical exam, asks about your symptoms, and recommends blood testing to determine if another condition, such as hypothyroidism, is causing your symptoms. If the doctor does not find an underlying cause of your symptoms, he or she performs a psychological evaluation.
Thousands of Americans who are diagnosed with this condition every year are unable to work and hold employment due to their symptoms. If an individual is unable to work because of bipolar disorder, he or she may qualify for either Supplement Security Income (SSI) or Social Security Disability Insurance (SSDI).
A 2022 review found that people with moderate to severe symptoms of bipolar disorder were less likely than those with mild symptoms to be employed. Working with bipolar disorder can pose significant challenges, but the right job can also provide benefits. Those benefits extend beyond employment income.
The main sign of bipolar disorder is extreme mood swings that go from emotional highs to emotional lows. Manic episodes cause people to seem very energetic, euphoric, or irritable. During depressive episodes, your loved one may seem sad, upset, or tired all the time.
Without proper treatment, people with hypomania may develop severe mania or depression. "Bipolar disorder may also be present in a mixed state, in which you might experience both mania and depression at the same time.
People with bipolar experience both episodes of severe depression and episodes of mania – overwhelming joy, excitement or happiness, huge energy, a reduced need for sleep, and reduced inhibitions. The experience of bipolar is uniquely personal. No two people have exactly the same experience.
Genetics. Bipolar disorder tends to run in families. Children with a parent or sibling with the disorder have a higher chance of developing it than those without affected family members. Identical twins don't have the same risk of developing the illness.
Childhood traumatic events are risk factors for developing bipolar disorders, in addition to a more severe clinical presentation over time (primarily an earlier age at onset and an increased risk of suicide attempt and substance misuse).
Both the ADA and SSA consider bipolar disorder a disability. That qualifies you to get extra protection and benefits under the law. To start the process, talk with your doctor. You will need documents to prove to the government that bipolar disorder affects your ability to work.